General Overview:
Toxicology (from the Greek words toxicon and logos ) is the study of the adverse effects of chemicals on living organisms. It is the study of symptoms, mechanisms, treatments and detection of poisoning, especially the poisoning of people. The chief criterion regarding the toxicity of a chemical is the dose, i.e. the amount of exposure to the substance. It is safe to say that almost all substances are toxic under the right conditions. As Paracelsus, the father of modern toxicology said, Sola dosis facit venenum (only dose determines the poison). Paracelsus, who lived in the 16th century was the first person to explain the dose-response relationship of toxic substances.
Many substances regarded as poisons are toxic only indirectly. An example is "wood alcohol" or methanol, which is not poisonous itself, but is chemically converted to toxic formaldehyde in the liver. Many drug molecules are made toxic in the liver, a good example being acetaminophen (paracetamol), especially in the presence of alcohol. The genetic variability of certain liver enzymes makes the toxicity of many compounds differ between one individual and the next. Because demands placed on one liver enzyme can induce activity in another, many molecules become toxic only in combination with others. A family of activities that engages many toxicologists includes identifying which liver enzymes convert a molecule into a poison, what are the toxic products of the conversion and under what conditions and in which individuals this conversion takes place.
The term LD50 refers to the dose of a toxic substance that kills 50 percent of a test population (typically rats or other surrogates when the test concerns human toxicity). LD50 estimations in animals became obsolete in 1991 and are no longer required for regulatory submissions as a part of pre-clinical development package.
The term Multiple chemical sensitivity is a controversial diagnosis indicating that a person suffers from allergy symptoms caused by trace amounts of environmental chemicals.
Mathieu Orfila is considered to be the father of toxicology, having given the subject its first formal treatment in 1813 in his Trait des poisons , also called Toxicologie generate .
However, Auroleus Phillipus Theostratus Bombastus von Hohenheim (1493 - 1541) (also refered to as Peracelsus or Paracelsus, from his belief that he was above or beyond the work of Celsus - the Roman physician from the first century) is widely regarded as "the" father of modern toxicology. He is credited with the suitable toxicology soundbite "All things are poison and nothing is without poison. It is the dose that makes a thing poisonous."
The term toxicology should not be confused with the term toxinology . Toxinology is the specialized area of toxicology that deals specifically with biological toxins, such as venoms or poisonous plants.
Toxicology Glossary
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Accuracy
Acute test
Acute-to-chronic ratio (ACR)
ANOVA
Average Monthly Limit (AML)
Bioaccumulation
Bioaccumulation Factor (BAF)
Bioassay
Bioconcentration
Biomonitoring
Chronic test
Chronic Value (ChrV)
Coefficient of Variation (CV)
Confidence limits (or intervals)
Control, negative
Control, positive
Control chart
Criteria Continuous Concentration (CCC)
Criteria Maximum Concentration (CMC)
Effect Concentration (EC)
Elutriate
False negative
False positive
Hypothesis Testing
Null Hypothesis (Ho)
Indigenous Species
Inhibition Concentration (IC)
Instream Waste Concentration (IWC)
Interstitial Water
LC50 (lethal concentration, 50 percent)
Life-cycle Test
LOEC (Lowest-observed-effect-concentration)
Long-term Averages (LTAs)
Maximum Daily Limit (MDL)
Minimum Significant Difference (MSD)
Mixing Zone
NOAEC (No-observed-acute-effect-concentration)
NOEC (No-observed-effect-concentration)
Nonparametric hypothesis tests
NPDES
Parametric hypothesis tests
Pathogen interference
Pore Water
Power
Precision
Proficiency Test Sample (PT)
Quality Assurance
Quality Control
Reference Toxicant
Replicate
Resident Species
Sediment
Surrogate Species
TAC (Test Acceptability Criteria)
Total Maximum Daily Load (TMDL)
Toxicity
Toxicity Identification Evaluation (TIE)
Toxicity Reduction Evaluation (TRE)
Toxicity Test
T.U.
Examples
Type I Error (alpha)
Type II Error (beta)
Waste Load Allocation (WLA)
Water Effects Ratio (WER)
Whole Effluent Toxicity (WET)
Whole Sediment
